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KMID : 0191120200350400366
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Journal of Korean Medical Science
2020 Volume.35 No. 40 p.366 ~ p.366
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Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study
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Kim Min-Kwan
Nam Jong-Ho
Son Jang-Won
Kim Sun-Oh
Son Nak-Hoon
Ahn Chul-Min
Shim Chi-Young
Hong Geu-Ru
Kim In-Cheol
Choi Jin-Woo
Kang Seung-Mo
Choi Yeoung-Ho
Yoon Hae-Kyoung
Uhm Jae-Sun
Jung In-Hyun
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Abstract
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Background: This study aimed to investigate the cardiac manifestations of coronavirus disease 2019 (COVID-19).
Methods: From February to March 2020, we prospectively and retrospectively enrolled consecutive patients diagnosed with COVID-19. Patient's data such as the demographic characteristics, symptoms, vital signs, laboratory and radiologic findings, electrocardiographic, and echocardiographic data, including the global longitudinal strain (GLS) of both ventricles, were obtained.
Results: Forty patients (median age, 58 years; 50% men) were enrolled in the initial analysis. Patients were classified into severe and nonsevere groups based on the current guidelines. The 13 patients in the severe group were significantly older, had a greater prevalence of bilateral pneumonia and leukocytosis, and higher aspartate transaminase levels than patients in the nonsevere group. Patients in the severe group had a slightly lower left ventricular ejection fraction (LVEF) than those in the nonsevere group (median [interquartile range], 61.0% [58.5%, 62.3%] vs. 66.7% [60.6%, 69.8%], P = 0.015). In a subgroup of 34 patients in whom GLS could be analyzed, patients in the severe group had a significantly impaired left ventricular GLS (LVGLS) than those in the nonsevere group (?18.1% [?18.8%, ?17.1%] vs. ?21.7% [?22.9%, ?19.9%], P = 0.001). There were no significant differences in total wall (RVGLStotal, ?19.3% [?23.9%, ?18.4%] vs. ?24.3% [?26.0%, ?22.6%], P = 0.060) and free wall (RVGLSfw, ?22.7% [?27.2%, ?18.6%] vs. ?28.8% [?30.4%, ?24.1%], P = 0.066) right ventricle GLS (RVGLS).
Conclusion: Patients with severe COVID-19 had lower LVEF and LVGLS. RVGLS was not different between patients with severe and nonsevere COVID-19.
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KEYWORD
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Coronavirus, COVID-19, Echocardiography, Global Longitudinal Strain, Ejection Fraction, Disease Severity
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